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Details on Person UniProt:Q9WTK8-2 Spo11
| Class:Id | ReferenceIsoform:154304 |
|---|---|
| _chainChangeLog | chain:1-396 added on Fri February 6 2015 |
| _displayName | UniProt:Q9WTK8-2 Spo11 |
| _timestamp | 2026-02-20 21:54:20 |
| chain | chain:1-396 |
| checksum | F4B9723C02844A5E |
| comment | FUNCTION Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761).FUNCTION In contrast to isoform 1, does not mediate DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.CATALYTIC ACTIVITY ATP-dependent breakage, passage and rejoining of double-stranded DNA.COFACTOR Heterotetramer of SPO11 and 2 TOP6BL chains (Probable). Interacts with TOP6BL (PubMed:26917764).SUBUNIT Does not interact with TOP6BL (PubMed:26917764).SUBCELLULAR LOCATION High levels are found only in the testis where expression is restricted primarily to meiotic germ cells. Not expressed in spermatogonia. Highest levels are found in pachytene spermatocytes. Very low levels are found in thymus, brain and oocytes of embryonic ovary. Not detected in adult ovary (PubMed:10622720, PubMed:10855504). Isoform 1: Expressed early in meiosis, when most double-strand breaks (DSB) are formed (PubMed:21330546).DEVELOPMENTAL STAGE Not detected at day 7 postpartum (dpp). Levels are low at 12 dpp but increase by 17 dpp. High levels are maintained throughout the remainder of testis development.SIMILARITY Belongs to the TOP6A family. |
| description | recommendedName: Meiotic recombination protein SPO11 ecNumber evidence="15"5.6.2.2 |
| geneName | Spo11 |
| identifier | Q9WTK8 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing DNA-binding Isomerase Magnesium Meiosis Metal-binding Nucleus Reference proteome Topoisomerase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645058] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Spo11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPO11_MOUSE Q8VIH6 Q9QUK2 Q9QY57 Q9QZS1 |
| sequenceLength | 396 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q9WTK8-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9WTK8-2 Spo11 (154304)
