Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9NTJ3-2 SMC4
| Class:Id | ReferenceIsoform:154063 |
|---|---|
| _chainChangeLog | chain:1-1288 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NTJ3-2 SMC4 |
| _timestamp | 2024-11-03 19:58:38 |
| chain | chain:1-1288 |
| checksum | 9D164D6EB0602464 |
| comment | FUNCTION Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SUBUNIT Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.ALTERNATIVE PRODUCTS Widely expressed. Higher expression in testis, colon, thymus.DOMAIN The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.SIMILARITY Belongs to the SMC family. SMC4 subfamily. |
| description | recommendedName: Structural maintenance of chromosomes protein 4 shortName: SMC protein 4 shortName: SMC-4 alternativeName: Chromosome-associated polypeptide C shortName: hCAP-C alternativeName: XCAP-C homolog |
| geneName | SMC4 CAPC SMC4L1 |
| identifier | Q9NTJ3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Chromosome Coiled coil Cytoplasm DNA condensation Mitosis Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SMC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001442] ENSEMBL:ENSG00000113810 SMC4 [Homo sapiens] |
| secondaryIdentifier | SMC4_HUMAN A6NLT9 D3DNL8 O95752 Q8NDL4 Q9UNT9 |
| sequenceLength | 1288 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NTJ3-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NTJ3-2 SMC4 (154063)
