Query author contributions in Reactome
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Details on Person UniProt:O75093 SLIT1
| Class:Id | ReferenceGeneProduct:154031 |
|---|---|
| _chainChangeLog | signal peptide:1-33 added on Fri February 6 2015;chain:34-1534 added on Fri February 6 2015 |
| _displayName | UniProt:O75093 SLIT1 |
| _timestamp | 2024-11-03 19:54:00 |
| chain | signal peptide:1-33 chain:34-1534 |
| checksum | 47B11CE6704A3E1D |
| comment | FUNCTION Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.SUBUNIT Interacts with ROBO1 and GREM1.INTERACTION Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Slit homolog 1 protein shortName: Slit-1 alternativeName: Multiple epidermal growth factor-like domains protein 4 shortName: Multiple EGF-like domains protein 4 |
| geneName | SLIT1 KIAA0813 MEGF4 SLIL1 |
| identifier | O75093 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Differentiation Disulfide bond EGF-like domain Glycoprotein Leucine-rich repeat Neurogenesis Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SLIT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998004] ENSEMBL:ENSG00000187122 SLIT1 [Homo sapiens] |
| secondaryIdentifier | SLIT1_HUMAN Q5T0V1 Q8WWZ2 Q9UIL7 |
| sequenceLength | 1534 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154032] UniProt:O75093-2 SLIT1 [Homo sapiens] [ReferenceIsoform:401807] UniProt:O75093-1 SLIT1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:204359] SLIT1 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75093 SLIT1 (154031)
