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Details on Person UniProt:O43166 SIPA1L1
| Class:Id | ReferenceGeneProduct:153925 |
|---|---|
| _chainChangeLog | chain:1-1804 added on Fri February 6 2015 |
| _displayName | UniProt:O43166 SIPA1L1 |
| _timestamp | 2024-11-03 19:53:58 |
| chain | chain:1-1804 |
| checksum | 91AB6AB4E7F47B2F |
| comment | FUNCTION Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).SUBUNIT Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.INTERACTION Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity).ALTERNATIVE PRODUCTS Widely expressed.PTM Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.PTM Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity). |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Signal-induced proliferation-associated 1-like protein 1 shortName: SIPA1-like protein 1 alternativeName: High-risk human papilloma viruses E6 oncoproteins targeted protein 1 shortName: E6-targeted protein 1 |
| geneName | SIPA1L1 E6TP1 KIAA0440 |
| identifier | O43166 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Cytoskeleton GTPase activation Methylation Phosphoprotein Proteomics identification Reference proteome Synapse Synaptosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SIPA1L1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962203] ENSEMBL:ENSG00000197555 SIPA1L1 [Homo sapiens] |
| secondaryIdentifier | SI1L1_HUMAN J3KP19 O95321 Q9UDU4 Q9UNU4 |
| sequenceLength | 1804 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153926] UniProt:O43166-2 SIPA1L1 [Homo sapiens] [ReferenceIsoform:401489] UniProt:O43166-1 SIPA1L1 [Homo sapiens] [ReferenceIsoform:8968052] UniProt:O43166-3 SIPA1L1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6794278] SPAR [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43166 SIPA1L1 (153925)
