Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9BX66-10 SORBS1
| Class:Id | ReferenceIsoform:153597 |
|---|---|
| _chainChangeLog | chain:1-1292 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BX66-10 SORBS1 |
| _timestamp | 2024-11-03 20:21:37 |
| chain | chain:1-1292 |
| checksum | 70DA4169B6D82F06 |
| comment | FUNCTION Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).SUBUNIT Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN.INTERACTION Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.ALTERNATIVE PRODUCTS Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.PTM O-glycosylated.MISCELLANEOUS Derived from mouse ortholog data.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Sorbin and SH3 domain-containing protein 1 alternativeName: Ponsin alternativeName: SH3 domain protein 5 alternativeName: SH3P12 alternativeName: c-Cbl-associated protein shortName: CAP |
| geneName | SORBS1 KIAA0894 KIAA1296 SH3D5 |
| identifier | Q9BX66 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Cell membrane Cytoplasm Cytoskeleton Glycoprotein Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SORBS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996886] ENSEMBL:ENSG00000095637 SORBS1 [Homo sapiens] |
| secondaryIdentifier | SRBS1_HUMAN A0AED4 A6NEK3 A6NID8 A6NJS4 A7MD40 D3DR42 O43857 Q5T923 Q5T924 Q5T927 Q5T928 Q5T929 Q5T930 Q5T931 Q5T932 Q7LBE5 Q8IVK0 Q8IVQ4 Q96KF3 Q96KF4 Q9BX64 Q9BX65 Q9P2Q0 Q9UFT2 Q9UHN7 Q9Y338 |
| sequenceLength | 1292 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BX66-10 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BX66-10 SORBS1 (153597)
