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Details on Person UniProt:Q9BX66 SORBS1

Class:IdReferenceGeneProduct:153588
_chainChangeLogchain:1-1292 added on Fri February 6 2015
_displayNameUniProt:Q9BX66 SORBS1
_timestamp2024-11-03 20:21:37
chainchain:1-1292
checksum70DA4169B6D82F06
commentFUNCTION Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).SUBUNIT Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN.INTERACTION Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.ALTERNATIVE PRODUCTS Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.PTM O-glycosylated.MISCELLANEOUS Derived from mouse ortholog data.SEQUENCE CAUTION Extended N-terminus.
created[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
descriptionrecommendedName: Sorbin and SH3 domain-containing protein 1 alternativeName: Ponsin alternativeName: SH3 domain protein 5 alternativeName: SH3P12 alternativeName: c-Cbl-associated protein shortName: CAP
geneNameSORBS1
KIAA0894
KIAA1296
SH3D5
identifierQ9BX66
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Cell junction
Cell membrane
Cytoplasm
Cytoskeleton
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
Transport
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameSORBS1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8996886] ENSEMBL:ENSG00000095637 SORBS1 [Homo sapiens]
secondaryIdentifierSRBS1_HUMAN
A0AED4
A6NEK3
A6NID8
A6NJS4
A7MD40
D3DR42
O43857
Q5T923
Q5T924
Q5T927
Q5T928
Q5T929
Q5T930
Q5T931
Q5T932
Q7LBE5
Q8IVK0
Q8IVQ4
Q96KF3
Q96KF4
Q9BX64
Q9BX65
Q9P2Q0
Q9UFT2
Q9UHN7
Q9Y338
sequenceLength1292
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:153589] UniProt:Q9BX66-2 SORBS1 [Homo sapiens]
[ReferenceIsoform:153590] UniProt:Q9BX66-3 SORBS1 [Homo sapiens]
[ReferenceIsoform:153591] UniProt:Q9BX66-4 SORBS1 [Homo sapiens]
[ReferenceIsoform:153592] UniProt:Q9BX66-5 SORBS1 [Homo sapiens]
[ReferenceIsoform:153593] UniProt:Q9BX66-6 SORBS1 [Homo sapiens]
[ReferenceIsoform:153594] UniProt:Q9BX66-7 SORBS1 [Homo sapiens]
[ReferenceIsoform:153595] UniProt:Q9BX66-8 SORBS1 [Homo sapiens]
[ReferenceIsoform:153596] UniProt:Q9BX66-9 SORBS1 [Homo sapiens]
[ReferenceIsoform:153597] UniProt:Q9BX66-10 SORBS1 [Homo sapiens]
[ReferenceIsoform:413474] UniProt:Q9BX66-1 SORBS1 [Homo sapiens]
List all 12 refering instances
(referenceEntity)[EntityWithAccessionedSequence:445795] SORBS1 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9BX66 SORBS1 (153588)
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