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Details on Person UniProt:Q96N87 SLC6A18
| Class:Id | ReferenceGeneProduct:153530 |
|---|---|
| _chainChangeLog | chain:1-628 added on Fri February 6 2015 |
| _displayName | UniProt:Q96N87 SLC6A18 |
| _timestamp | 2023-11-03 18:34:02 |
| chain | chain:1-628 |
| checksum | DDFA217424060095 |
| comment | FUNCTION Does not show neutral amino acid transporter activity.SUBCELLULAR LOCATION Abundantly expressed in kidney, but not in intestine.POLYMORPHISM Genetic variation in SLC6A18 is not a significant predictor for elevated systolic or diastolic blood pressure and is not associated with hypertension in the Japanese population (PubMed:16340170).DISEASE Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20 (PubMed:19033659).SIMILARITY Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily.CAUTION The mouse ortholog protein is an active neutral amino acid transporter. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Inactive sodium-dependent neutral amino acid transporter B(0)AT3 alternativeName: fullName evidence="8"Sodium- and chloride-dependent transporter XTRP2 alternativeName: Solute carrier family 6 member 18 alternativeName: System B(0) neutral amino acid transporter AT3 |
| geneName | SLC6A18 B0AT3 XTRP2 |
| identifier | Q96N87 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid transport Glycoprotein Membrane Neurotransmitter transport Reference proteome Symport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SLC6A18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002624] ENSEMBL:ENSG00000164363 SLC6A18 [Homo sapiens] |
| secondaryIdentifier | S6A18_HUMAN |
| sequenceLength | 628 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:352020] SLC6A18 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5659726] SLC6A18 G496R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5659751] SLC6A18 G79S [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5659724] glycine 496 replaced with L-arginine [ReplacedResidue:5659750] glycine 79 replaced with L-serine |
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No pathways have been reviewed or authored by UniProt:Q96N87 SLC6A18 (153530)
