Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9NP59 SLC40A1

Class:Id	ReferenceGeneProduct:153505
_chainChangeLog	chain:1-571 added on Fri February 6 2015
_displayName	UniProt:Q9NP59 SLC40A1
_timestamp	2026-02-20 22:59:53
chain	chain:1-571
checksum	E4D6B5594C904959
comment	FUNCTION Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).CATALYTIC ACTIVITY Fe(2+)(in) = Fe(2+)(out)SUBUNIT Identified in a complex with STOM (PubMed:23219802). Interacts with HAMP; affinity of the peptide hormone HAMP for SLC40A1 increases by 80-fold in the presence of iron and the interaction promotes SLC40A1 ubiquitination and degradation (PubMed:22682227, PubMed:29237594, PubMed:32814342). Part of a complex composed of SLC40A1/ferroportin, TF/transferrin and HEPH/hephaestin that transfers iron from cells to transferrin (PubMed:37277838).INTERACTION Localized to the basolateral membrane of hepatocytoma WIF-B cells.TISSUE SPECIFICITY Detected in erythrocytes (at protein level) (PubMed:23219802). Expressed in placenta, intestine, muscle and spleen (PubMed:10747949). Highly expressed in mature red blood (PubMed:29599243).PTM Polyubiquitinated by RNF217; leading to proteasomal degradation (By similarity). Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells (PubMed:22682227, PubMed:37277838).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.CAUTION Manganese Mn(2+) transport by SLC40A1 remains controversial. Some in vitro studies have suggested that SLC40A1 transports minimal amounts of Mn(2+) (PubMed:22178646, PubMed:30247984). Other groups have suggested that it does not (PubMed:24304836, PubMed:29792530). The affinity of SLC40A1 for Mn(2+) is extremely low compared with iron, implying that any SLC40A1-mediated Mn(2+) transport in vivo would likely be trivial (PubMed:24304836). A recent study examined the role of SLC40A1 in Mn(2+) homeostasis by using Tmprss6-O mice, which express high levels of hepcidin/HAMP and therefore have very low SLC40A1 levels in their tissues. These mice show frank iron deficiency and reduced iron levels in most tissues, but manganese levels are largely unaffected (By similarity). These studies suggest that manganese is probably not the physiological substrate of SLC40A1.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
description	recommendedName: fullName evidence="33"Ferroportin alternativeName: Ferroportin-1 alternativeName: Iron-regulated transporter 1 alternativeName: fullName evidence="35"Solute carrier family 40 member 1
geneName	SLC40A1 FPN FPN1 IREG1 SLC11A3 MSTP079
identifier	Q9NP59
isSequenceChanged	FALSE
keyword	3D-structure Cell membrane Disease variant Glycoprotein Ion transport Iron Iron transport Membrane Metal-binding Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	SLC40A1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:5660075] ENSEMBL:ENSG00000138449 SLC40A1 [Homo sapiens]
secondaryIdentifier	S40A1_HUMAN Q6FI62 Q7Z4F8 Q8IVB2 Q9NRL0
sequenceLength	571
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:442390] SLC40A1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655697] SLC40A1 G80V [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655698] SLC40A1 A77D [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655754] SLC40A1 N144H [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655786] SLC40A1 D181V [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655794] SLC40A1 D157G [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5655818] SLC40A1 V162del [plasma membrane] [Homo sapiens]
(referenceSequence)	[FragmentDeletionModification:5655728] Deletion of residues 162 to 162 [ReplacedResidue:5655731] L-asparagine 144 replaced with L-histidine [ReplacedResidue:5655779] L-aspartic acid 181 replaced with L-valine [ReplacedResidue:5655781] L-alanine 77 replaced with L-aspartic acid [ReplacedResidue:5655805] glycine 80 replaced with L-valine [ReplacedResidue:5655817] L-aspartic acid 157 replaced with glycine
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9NP59 SLC40A1 (153505)