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Details on Person UniProt:Q9NVU0-2 POLR3E
| Class:Id | ReferenceIsoform:153249 |
|---|---|
| _chainChangeLog | chain:1-708 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NVU0-2 POLR3E |
| _timestamp | 2024-11-03 19:43:14 |
| chain | chain:1-708 |
| checksum | E9DB71615CC367A5 |
| comment | FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).SUBUNIT Component of the RNA polymerase III complex consisting of at least 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; the stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, forming a structural mobile part that protrudes out of the core and functions primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3D/RPC4-POLR3E/RPC5 heterodimer and POLR3/CRPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer.SUBCELLULAR LOCATION May result from the retention of an intron in the cDNA. |
| description | recommendedName: DNA-directed RNA polymerase III subunit RPC5 shortName: RNA polymerase III subunit C5 alternativeName: DNA-directed RNA polymerase III 80 kDa polypeptide |
| geneName | POLR3E KIAA1452 |
| identifier | Q9NVU0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Antiviral defense DNA-directed RNA polymerase Immunity Innate immunity Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | POLR3E |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990949] ENSEMBL:ENSG00000058600 POLR3E [Homo sapiens] |
| secondaryIdentifier | RPC5_HUMAN B4DL24 B4DUP6 H3BT11 Q9BWF7 Q9H8W8 Q9H907 Q9P276 |
| sequenceLength | 708 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NVU0-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NVU0-2 POLR3E (153249)
