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Details on Person UniProt:Q9BUI4 POLR3C
| Class:Id | ReferenceGeneProduct:153246 |
|---|---|
| _chainChangeLog | chain:1-534 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BUI4 POLR3C |
| _timestamp | 2024-11-03 20:16:25 |
| chain | chain:1-534 |
| checksum | 0E4CFEE295EE1A55 |
| comment | FUNCTION DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:35637192). Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:33558764, PubMed:33558766). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).SUBUNIT Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination (PubMed:12391170, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218, PubMed:35637192, PubMed:9171375). Directly interacts with POLR3G/RPC7 and POLR3GL (PubMed:21358628, PubMed:24107381, PubMed:26394183). Directly interacts with POLR3F/RPC6 (PubMed:26394183). Interacts with GTF3C4 (PubMed:10523658). As part of the RNA polymerase III complex, interacts with PKP2 (PubMed:11416169).INTERACTION Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).SIMILARITY Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: DNA-directed RNA polymerase III subunit RPC3 shortName: RNA polymerase III subunit C3 alternativeName: DNA-directed RNA polymerase III subunit C alternativeName: RNA polymerase III 62 kDa subunit shortName: RPC62 |
| geneName | POLR3C |
| identifier | Q9BUI4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antiviral defense DNA-binding DNA-directed RNA polymerase Immunity Innate immunity Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | POLR3C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990376] ENSEMBL:ENSG00000186141 POLR3C [Homo sapiens] |
| secondaryIdentifier | RPC3_HUMAN O15317 Q9Y3R6 |
| sequenceLength | 534 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1964430] POLR3C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1964448] POLR3C [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BUI4 POLR3C (153246)
