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Details on Person UniProt:Q14103-4 HNRNPD
| Class:Id | ReferenceIsoform:153186 |
|---|---|
| _chainChangeLog | chain:1-355 added on Fri February 6 2015;chain:1-355 removed on Fri May 8 2015;initiator methionine:1 added on Fri May 8 2015;chain:2-355 added on Fri May 8 2015;initiator methionine:1 for 153186 removed on Fri Nov 03 2023;initiator methionine: for 153186 added on Fri Nov 03 2023;initiator methionine: for 153186 removed on Fri Aug 15 2025;initiator methionine:1 for 153186 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q14103-4 HNRNPD |
| _timestamp | 2025-08-15 21:15:26 |
| chain | initiator methionine:1 chain:2-355 |
| checksum | D0B6EA177BEF789E |
| comment | FUNCTION Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3.INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.ALTERNATIVE PRODUCTS Arg-345 is dimethylated, probably to asymmetric dimethylarginine.PTM Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Several sequence conflicts. |
| description | recommendedName: Heterogeneous nuclear ribonucleoprotein D0 shortName: hnRNP D0 alternativeName: AU-rich element RNA-binding protein 1 |
| geneName | HNRNPD AUF1 HNRPD |
| identifier | Q14103 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Biological rhythms Cytoplasm Direct protein sequencing DNA-binding Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HNRNPD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962291] ENSEMBL:ENSG00000138668 HNRNPD [Homo sapiens] |
| secondaryIdentifier | HNRPD_HUMAN A8K9J2 P07029 Q01858 Q14100 Q14101 Q14102 Q4W5A1 Q9UCE8 Q9UCE9 |
| sequenceLength | 355 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q14103-4 |
| (referenceEntity) | [EntityWithAccessionedSequence:450442] HNRNPD-4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:451232] Ub-HNRNPD-4 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:451179] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q14103-4 HNRNPD (153186)
