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Details on Person UniProt:Q9Y6N7 ROBO1
| Class:Id | ReferenceGeneProduct:153145 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-1651 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y6N7 ROBO1 |
| _timestamp | 2026-02-20 23:10:32 |
| chain | signal peptide:1-25 chain:26-1651 |
| checksum | 9D98CD7CAB73074D |
| comment | FUNCTION Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).SUBUNIT Homodimer. Dimerization is mediated by the extracellular domain and is independent of SLIT liganding (PubMed:24673457). Interacts with SLIT1 (By similarity). Interacts with SLIT2 (PubMed:10102268, PubMed:11404413, PubMed:17848514). Interacts with FLRT3 (PubMed:24560577). Interacts with MYO9B (via Rho-GAP domain) (PubMed:26529257).SUBCELLULAR LOCATION Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).ALTERNATIVE PRODUCTS Widely expressed, with exception of kidney.PTM Ubiquitinated. May be deubiquitinated by USP33.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS Maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. The promoter region of ROBO1 shows complete hypermethylation of CpG sites in the BT-20 breast tumor cell lines, some primary invasive breast carcinomasa and some primary clear cell renal cell carcinomas (CC-RCC).MISCELLANEOUS Incomplete.SIMILARITY Belongs to the immunoglobulin superfamily. ROBO family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Roundabout homolog 1 alternativeName: Deleted in U twenty twenty alternativeName: H-Robo-1 |
| geneName | ROBO1 DUTT1 |
| identifier | Q9Y6N7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cell projection Chemotaxis Developmental protein Differentiation Disease variant Disulfide bond Dwarfism Glycoprotein Immunoglobulin domain Intellectual disability Membrane Neurogenesis Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ROBO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000819] ENSEMBL:ENSG00000169855 ROBO1 [Homo sapiens] |
| secondaryIdentifier | ROBO1_HUMAN B2RXI1 D3DU36 E9PD49 Q1RMC7 Q7Z300 Q9BUS7 |
| sequenceLength | 1651 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153146] UniProt:Q9Y6N7-2 ROBO1 [Homo sapiens] [ReferenceIsoform:153147] UniProt:Q9Y6N7-3 ROBO1 [Homo sapiens] [ReferenceIsoform:416132] UniProt:Q9Y6N7-1 ROBO1 [Homo sapiens] [ReferenceIsoform:8968034] UniProt:Q9Y6N7-4 ROBO1 [Homo sapiens] [ReferenceIsoform:8968035] UniProt:Q9Y6N7-5 ROBO1 [Homo sapiens] [ReferenceIsoform:8968036] UniProt:Q9Y6N7-6 ROBO1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:204361] ROBO1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:375979] p-Y1073-ROBO1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8986095] PolyUb-ROBO1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:375978] O4'-phospho-L-tyrosine at 1073 [GroupModifiedResidue:8986091] ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9Y6N7 ROBO1 (153145)
