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Details on Person UniProt:Q9BQ52 ELAC2
| Class:Id | ReferenceGeneProduct:153122 |
|---|---|
| _chainChangeLog | transit peptide:1-16 added on Sat February 7 2015;chain:17-826 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BQ52 ELAC2 |
| _timestamp | 2025-02-21 19:42:34 |
| chain | transit peptide:1-16 chain:17-826 |
| checksum | 4AE701C755EC7339 |
| comment | FUNCTION Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694).CATALYTIC ACTIVITY Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.COFACTOR Homodimer (By similarity). Interacts with PTCD1.SUBCELLULAR LOCATION Mainly mitochondrial.ALTERNATIVE PRODUCTS Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the RNase Z family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Zinc phosphodiesterase ELAC protein 2 ecNumber: 3.1.26.11 alternativeName: ElaC homolog protein 2 alternativeName: Heredity prostate cancer protein 2 alternativeName: Ribonuclease Z 2 shortName: RNase Z 2 alternativeName: tRNA 3 endonuclease 2 alternativeName: tRNase Z 2 |
| geneName | ELAC2 HPC2 |
| identifier | Q9BQ52 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Endonuclease Hydrolase Metal-binding Mitochondrion Mitochondrion nucleoid Nuclease Nucleus Phosphoprotein Primary mitochondrial disease Proteomics identification Proto-oncogene Reference proteome Transit peptide tRNA processing Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ELAC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962107] ENSEMBL:ENSG00000006744 ELAC2 [Homo sapiens] |
| secondaryIdentifier | RNZ2_HUMAN B4DPL9 Q6IA94 Q9HAS8 Q9HAS9 Q9NVT1 |
| sequenceLength | 826 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:153123] UniProt:Q9BQ52-2 ELAC2 [Homo sapiens] [ReferenceIsoform:153124] UniProt:Q9BQ52-3 ELAC2 [Homo sapiens] [ReferenceIsoform:413329] UniProt:Q9BQ52-1 ELAC2 [Homo sapiens] [ReferenceIsoform:8974876] UniProt:Q9BQ52-4 ELAC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5696766] ELAC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6786837] ELAC2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9708824] ELAC2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BQ52 ELAC2 (153122)
