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Details on Person UniProt:Q9H0U6 MRPL18
| Class:Id | ReferenceGeneProduct:153065 |
|---|---|
| _chainChangeLog | transit peptide:1- added on Sat February 7 2015;chain:-180 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H0U6 MRPL18 |
| _timestamp | 2024-11-03 19:58:20 |
| chain | transit peptide:1- chain:-180 |
| checksum | C0CAD23465FE93B4 |
| comment | FUNCTION Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.SUBUNIT Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:28892042, PubMed:35177605). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.INTERACTION Belongs to the universal ribosomal protein uL18 family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="7"Large ribosomal subunit protein uL18m alternativeName: 39S ribosomal protein L18, mitochondrial shortName: L18mt shortName: MRP-L18 |
| geneName | MRPL18 HSPC071 |
| identifier | Q9H0U6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chaperone Mitochondrion Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding Transit peptide Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MRPL18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:4793745] ENSEMBL:ENSG00000112110 MRPL18 [Homo sapiens] |
| secondaryIdentifier | RM18_HUMAN Q5TAP9 Q9NZW8 |
| sequenceLength | 180 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5368207] MRPL18 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H0U6 MRPL18 (153065)
