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Details on Person UniProt:Q96AH8 RAB7B
| Class:Id | ReferenceGeneProduct:152783 |
|---|---|
| _chainChangeLog | chain:1-199 added on Fri February 6 2015 |
| _displayName | UniProt:Q96AH8 RAB7B |
| _timestamp | 2025-08-15 21:18:09 |
| chain | chain:1-199 |
| checksum | 161C41ABC0EBA529 |
| comment | FUNCTION Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.INTERACTION Recruited to phagosomes containing S.aureus or M.tuberculosis.TISSUE SPECIFICITY Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Ras-related protein Rab-7b |
| geneName | RAB7B |
| identifier | Q96AH8 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasmic vesicle Endosome Golgi apparatus GTP-binding Lipoprotein Lysosome Membrane Nucleotide-binding Phosphoprotein Prenylation Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RAB7B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000268] ENSEMBL:ENSG00000276600 RAB7B [Homo sapiens] |
| secondaryIdentifier | RAB7B_HUMAN |
| sequenceLength | 199 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8854158] RAB7B [late endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:8873707] RAB7B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8874059] GGC-RAB7B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8877450] GGC-RAB7B [lysosomal membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8874060] S-geranylgeranyl-L-cysteine at 198 [ModifiedResidue:8874062] S-geranylgeranyl-L-cysteine at 199 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96AH8 RAB7B (152783)
