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Details on Person UniProt:Q91V41 Rab14
| Class:Id | ReferenceGeneProduct:152767 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-215 added on Fri February 6 2015;initiator methionine:1 for 152767 removed on Fri Nov 03 2023;initiator methionine: for 152767 added on Fri Nov 03 2023;initiator methionine: for 152767 removed on Fri Aug 15 2025;initiator methionine:1 for 152767 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q91V41 Rab14 |
| _timestamp | 2026-02-20 22:37:13 |
| chain | initiator methionine:1 chain:2-215 |
| checksum | BC8A8B98FB9944AC |
| comment | FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (PubMed:21238925). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) including DENND6A and DENND6B which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation.SUBUNIT Interacts with ZFYVE20 (By similarity). Interacts with KIF16B (PubMed:21238925). Interacts (GTP-bound form) with RUFY1; the interaction recruits RUFY1 onto endosomal membranes (By similarity). Interacts (GTP-bound form) with RAB11FIP1 (via its C-terminus); the interactions doesn't mediate RAB11FIP1 rectruitment to membranes (By similarity). Interacts with RAB11FIP2 (By similarity).SUBCELLULAR LOCATION Recruited to recycling endosomes by DENND6A.DOMAIN Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Ras-related protein Rab-14 ecNumber evidence="2"3.6.5.2 |
| geneName | Rab14 |
| identifier | Q91V41 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasmic vesicle Direct protein sequencing Endosome Golgi apparatus GTP-binding Hydrolase Lipoprotein Magnesium Membrane Metal-binding Methylation Nucleotide-binding Prenylation Protein transport Reference proteome Transport |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Rab14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RAB14_MOUSE |
| sequenceLength | 215 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1445087] GGC-Rab14 [cytoplasmic vesicle membrane] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9605136] S-geranylgeranyl-L-cysteine at 215 [ModifiedResidue:9605147] S-geranylgeranyl-L-cysteine at 213 |
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No pathways have been reviewed or authored by UniProt:Q91V41 Rab14 (152767)
