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Details on Person UniProt:Q9HB21 PLEKHA1
| Class:Id | ReferenceGeneProduct:152165 |
|---|---|
| _chainChangeLog | chain:1-404 added on Sat February 7 2015 |
| _displayName | UniProt:Q9HB21 PLEKHA1 |
| _timestamp | 2024-11-03 20:11:30 |
| chain | chain:1-404 |
| checksum | 6855CD58E1A80F8A |
| comment | FUNCTION Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.SUBUNIT Interacts with MPDZ and PTPN13.INTERACTION Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.ALTERNATIVE PRODUCTS Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.DOMAIN Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Pleckstrin homology domain-containing family A member 1 shortName: PH domain-containing family A member 1 alternativeName: Tandem PH domain-containing protein 1 shortName: TAPP-1 |
| geneName | PLEKHA1 TAPP1 |
| identifier | Q9HB21 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytoplasm Lipid-binding Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLEKHA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993819] ENSEMBL:ENSG00000107679 PLEKHA1 [Homo sapiens] |
| secondaryIdentifier | PKHA1_HUMAN B3KQ55 D3DRE2 Q9BVK0 |
| sequenceLength | 404 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965297] UniProt:Q9HB21-1 PLEKHA1 [Homo sapiens] [ReferenceIsoform:8965298] UniProt:Q9HB21-2 PLEKHA1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8870328] PLEKHA1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HB21 PLEKHA1 (152165)
