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Details on Person UniProt:Q8VE62 Paip1

Class:IdReferenceGeneProduct:152123
_chainChangeLogchain:1-400 added on Fri February 6 2015
_displayNameUniProt:Q8VE62 Paip1
_timestamp2023-11-03 15:20:13
chainchain:1-400
checksumC5B8A18F068A5E6B
commentFUNCTION Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).SUBUNIT Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A (By similarity).SUBCELLULAR LOCATION Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
created[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
descriptionrecommendedName: Polyadenylate-binding protein-interacting protein 1 shortName: PABP-interacting protein 1 shortName: PAIP-1 shortName: Poly(A)-binding protein-interacting protein 1
geneNamePaip1
identifierQ8VE62
isSequenceChangedFALSE
keywordCytoplasm
Reference proteome
Translation regulation
modified[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9657908] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
namePaip1
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierPAIP1_MOUSE
Q9WUC9
sequenceLength400
species[Species:48892] Mus musculus
(referenceEntity)[EntityWithAccessionedSequence:9817650] Paip1 [cytosol] [Mus musculus]
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No pathways have been reviewed or authored by UniProt:Q8VE62 Paip1 (152123)