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Details on Person UniProt:P13608-2 ACAN
| Class:Id | ReferenceIsoform:151994 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Fri February 6 2015;chain:17-2364 added on Fri February 6 2015 |
| _displayName | UniProt:P13608-2 ACAN |
| _timestamp | 2025-08-15 21:55:28 |
| chain | signal peptide:1-16 chain:17-2364 |
| checksum | 6FF83763420C3D4C |
| comment | FUNCTION This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.SUBUNIT Forms a complex (via covalent bonds) with MATN1; the interaction increases with age of the organism via an increase in occupancy of MATN1 binding sites (PubMed:8943283). Interacts with FBLN1 (By similarity). Interacts with COMP (By similarity).INTERACTION Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM Contains mostly chondroitin sulfate, but also N-linked and O-linked (about 40) oligosaccharides.PTM The keratan sulfate contents differ considerably between adult and fetal bovine proteoglycans.SIMILARITY Belongs to the aggrecan/versican proteoglycan family. |
| description | recommendedName: Aggrecan core protein alternativeName: Cartilage-specific proteoglycan core protein shortName: CSPCP |
| geneName | ACAN AGC1 |
| identifier | P13608 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Direct protein sequencing Disulfide bond EGF-like domain Extracellular matrix Glycoprotein Immunoglobulin domain Lectin Metal-binding Proteoglycan Reference proteome Repeat Secreted Signal Sushi |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ACAN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PGCA_BOVIN P79117 Q28159 Q6XL66 |
| sequenceLength | 2364 |
| species | [Species:48898] Bos taurus |
| variantIdentifier | P13608-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P13608-2 ACAN (151994)
