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Details on Person UniProt:Q08024-3 Cbfb
| Class:Id | ReferenceIsoform:151952 |
|---|---|
| _chainChangeLog | chain:1-187 added on Fri February 6 2015 |
| _displayName | UniProt:Q08024-3 Cbfb |
| _timestamp | 2024-08-09 19:42:04 |
| chain | chain:1-187 |
| checksum | 0B2E6101A35D0FD8 |
| comment | FUNCTION Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3) (PubMed:12434156, PubMed:8386878, PubMed:8497254). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX (PubMed:12434156, PubMed:8386878, PubMed:8497254). The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (PubMed:11257229). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development (PubMed:18258917). They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917).SUBUNIT Heterodimer with RUNX1, RUNX2 and RUNX3 (PubMed:11257229, PubMed:12434156). Interacts with COPRS (PubMed:22193545). Found in a complex with PRMT5 and RUNX1 (PubMed:22193545).SUBCELLULAR LOCATION Expressed in all tissues tested (PubMed:8497254). Highest level in thymus, but also abundantly expressed in muscle, lung and brain (PubMed:8497254).MISCELLANEOUS Major isoform.MISCELLANEOUS Does not dimerize with the alpha subunit.MISCELLANEOUS Does not dimerize with the alpha subunit.SIMILARITY Belongs to the CBF-beta family. |
| description | recommendedName: Core-binding factor subunit beta shortName evidence="9"CBF-beta alternativeName: Polyomavirus enhancer-binding protein 2 beta subunit shortName: PEA2-beta shortName: PEBP2-beta alternativeName: SL3-3 enhancer factor 1 subunit beta alternativeName: SL3/AKV core-binding factor beta subunit |
| geneName | Cbfb Pebp2b Pebpb2 |
| identifier | Q08024 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Reference proteome |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Cbfb |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PEBB_MOUSE Q08025 Q62050 Q62051 Q8C282 Q8CGD5 |
| sequenceLength | 187 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q08024-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q08024-3 Cbfb (151952)
