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Details on Person UniProt:Q96RG2 PASK
| Class:Id | ReferenceGeneProduct:151812 |
|---|---|
| _chainChangeLog | chain:1-1323 added on Sat February 7 2015 |
| _displayName | UniProt:Q96RG2 PASK |
| _timestamp | 2025-02-21 19:41:16 |
| chain | chain:1-1323 |
| checksum | F8A3633CC6F6C8CD |
| comment | FUNCTION Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).INTERACTION Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.ALTERNATIVE PRODUCTS Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).DOMAIN The protein kinase domain mediates binding to phosphatidylinositol.PTM Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: PAS domain-containing serine/threonine-protein kinase shortName: PAS-kinase shortName: PASKIN shortName: hPASK ecNumber: 2.7.11.1 |
| geneName | PASK KIAA0135 |
| identifier | Q96RG2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Kinase Lipid-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PASK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988567] ENSEMBL:ENSG00000115687 PASK [Homo sapiens] |
| secondaryIdentifier | PASK_HUMAN G5E9F1 Q05BE4 Q68DY3 Q6GSJ5 Q86XH6 Q99763 Q9UFR7 |
| sequenceLength | 1323 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151813] UniProt:Q96RG2-2 PASK [Homo sapiens] [ReferenceIsoform:413064] UniProt:Q96RG2-1 PASK [Homo sapiens] [ReferenceIsoform:8966685] UniProt:Q96RG2-4 PASK [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9677168] PASK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9677184] PASK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9677197] p-T640,T642,S949,S953,S956-PASK [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9677195] O-phospho-L-threonine at 640 [ModifiedResidue:9677196] O-phospho-L-serine at 949 [ModifiedResidue:9677198] O-phospho-L-serine at 953 [ModifiedResidue:9677199] O-phospho-L-threonine at 642 [ModifiedResidue:9677202] O-phospho-L-serine at 956 |
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No pathways have been reviewed or authored by UniProt:Q96RG2 PASK (151812)
