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Details on Person UniProt:Q9NSP4 CENPM
| Class:Id | ReferenceGeneProduct:151719 |
|---|---|
| _chainChangeLog | chain:1-180 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NSP4 CENPM |
| _timestamp | 2024-11-03 19:55:36 |
| chain | chain:1-180 |
| checksum | 37DB044092BF63F4 |
| comment | FUNCTION Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.SUBUNIT Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.SUBCELLULAR LOCATION Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres.ALTERNATIVE PRODUCTS Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.MISCELLANEOUS Due to intron retention. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Centromere protein M shortName: CENP-M alternativeName: Interphase centromere complex protein 39 alternativeName: Proliferation-associated nuclear element protein 1 |
| geneName | CENPM C22orf18 ICEN39 PANE1 |
| identifier | Q9NSP4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Centromere Chromosome Cytoplasm Kinetochore Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CENPM |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000502] ENSEMBL:ENSG00000100162 CENPM [Homo sapiens] |
| secondaryIdentifier | CENPM_HUMAN A7LM22 B1AHQ9 Q6I9W3 |
| sequenceLength | 180 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151720] UniProt:Q9NSP4-2 CENPM [Homo sapiens] [ReferenceIsoform:222844] UniProt:Q9NSP4-3 CENPM [Homo sapiens] [ReferenceIsoform:414774] UniProt:Q9NSP4-1 CENPM [Homo sapiens] [ReferenceIsoform:8976431] UniProt:Q9NSP4-4 CENPM [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375290] CENPM [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5633506] CENPM [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NSP4 CENPM (151719)
