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Details on Person UniProt:Q8WXI9 GATAD2B
| Class:Id | ReferenceGeneProduct:151663 |
|---|---|
| _chainChangeLog | chain:1-593 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WXI9 GATAD2B |
| _timestamp | 2024-11-03 20:15:49 |
| chain | chain:1-593 |
| checksum | 5EB375C7EB24210B |
| comment | FUNCTION Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463).SUBUNIT Homooligomer (PubMed:27732854). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:27732854, PubMed:28977666, PubMed:33283408). Interacts with MBD2; this is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (PubMed:11756549, PubMed:12183469, PubMed:16415179, PubMed:27732854). Interacts with MBD3 (PubMed:11756549, PubMed:12183469, PubMed:27732854). Component of the MeCP1 histone deacetylase complex (PubMed:11756549). Interacts with histone tails, including that of histones H2A, H2B, H3 and H4 (PubMed:16415179). Interacts with ERCC6 (PubMed:26030138).INTERACTION Speckled nuclear localization requires both CR1 and CR2 regions (PubMed:16415179). Localizes to sites of DNA damage (PubMed:27732854).TISSUE SPECIFICITY Widely expressed.DOMAIN Both CR1 and CR2 regions are required for speckled nuclear localization.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Transcriptional repressor p66-beta alternativeName: GATA zinc finger domain-containing protein 2B alternativeName: p66/p68 |
| geneName | GATAD2B KIAA1150 |
| identifier | Q8WXI9 |
| isSequenceChanged | FALSE |
| keyword | Chromosome Coiled coil Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GATAD2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997336] ENSEMBL:ENSG00000143614 GATAD2B [Homo sapiens] |
| secondaryIdentifier | P66B_HUMAN D3DUZ2 Q5VUR2 Q7LG68 Q9ULS0 |
| sequenceLength | 593 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3702079] GATAD2B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9940398] monoSUMO1-K33 GATAD2B [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9940395] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 33 |
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No pathways have been reviewed or authored by UniProt:Q8WXI9 GATAD2B (151663)
