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Details on Person UniProt:P10451-3 SPP1
| Class:Id | ReferenceIsoform:151566 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Sat February 7 2015;chain:17-314 added on Sat February 7 2015 |
| _displayName | UniProt:P10451-3 SPP1 |
| _timestamp | 2025-08-15 21:25:05 |
| chain | signal peptide:1-16 chain:17-314 |
| checksum | 4996429EC4752B86 |
| comment | FUNCTION Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.FUNCTION Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.SUBUNIT Interacts (via N-terminus) with integrin ITGA9:ITGB1.INTERACTION Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Bone. Found in plasma.PTM Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.PTM Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (PubMed:15869464, PubMed:22582013, PubMed:26091039). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity).PTM O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.SIMILARITY Belongs to the osteopontin family.ONLINE INFORMATION Osteopontin entry |
| description | recommendedName: fullName evidence="16 17"Osteopontin alternativeName: Bone sialoprotein 1 alternativeName: Nephropontin alternativeName: Secreted phosphoprotein 1 shortName: SPP-1 alternativeName: fullName evidence="15"Urinary stone protein alternativeName: fullName evidence="15"Uropontin |
| geneName | SPP1 BNSP OPN PSEC0156 |
| identifier | P10451 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Biomineralization Cell adhesion Cytokine Direct protein sequencing Glycoprotein Phosphoprotein Proteoglycan Proteomics identification Reference proteome Secreted Sialic acid Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SPP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8952441] ENSEMBL:ENSG00000118785 SPP1 [Homo sapiens] |
| secondaryIdentifier | OSTP_HUMAN B2RDA1 Q15681 Q15682 Q15683 Q4W597 Q567T5 Q8NBK2 Q96IZ1 |
| sequenceLength | 314 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P10451-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P10451-3 SPP1 (151566)
