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Details on Person UniProt:Q9BZF3-2 OSBPL6
| Class:Id | ReferenceIsoform:151552 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-934 added on Fri February 6 2015;initiator methionine:1 for 151552 removed on Fri Nov 03 2023;initiator methionine: for 151552 added on Fri Nov 03 2023;initiator methionine: for 151552 removed on Fri Aug 15 2025;initiator methionine:1 for 151552 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BZF3-2 OSBPL6 |
| _timestamp | 2025-08-15 22:10:22 |
| chain | initiator methionine:1 chain:2-934 |
| checksum | D20F90EA34C81497 |
| comment | FUNCTION Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193).SUBUNIT Homodimer (By similarity). Interacts with OSBPL3 (By similarity).INTERACTION Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum.ALTERNATIVE PRODUCTS Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).DEVELOPMENTAL STAGE Expressed in fetal brain and lung.INDUCTION By acetylated low-density lipoprotein.SIMILARITY Belongs to the OSBP family. |
| description | recommendedName: Oxysterol-binding protein-related protein 6 shortName: ORP-6 shortName: OSBP-related protein 6 |
| geneName | OSBPL6 ORP6 |
| identifier | Q9BZF3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cell membrane Cytoplasm Endoplasmic reticulum Endosome Lipid transport Lipid-binding Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | OSBPL6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000743] ENSEMBL:ENSG00000079156 OSBPL6 [Homo sapiens] |
| secondaryIdentifier | OSBL6_HUMAN B4DTW1 C4AMC0 C4AME4 D3DPF6 D3DPF7 Q4ZG68 Q53T68 Q59H61 Q7Z4Q1 Q86V84 Q8N9T0 Q96SR1 |
| sequenceLength | 934 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BZF3-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BZF3-2 OSBPL6 (151552)
