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Details on Person ubiquitin activating enzyme activity

Class:Id	GO_MolecularFunction:15143
_displayName	ubiquitin activating enzyme activity
_timestamp	2009-11-21 18:39:34
accession	0004839
definition	Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
ecNumber	6.2.1.45
modified	[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35 [InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09 [InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16 [InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20 [InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39 [InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04 [InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44 [InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57 [InstanceEdit:422569] Kanapin, EE [InstanceEdit:436347] Kanapin, EE [InstanceEdit:447572] Kanapin, EE [InstanceEdit:526073] Kanapin, AA [InstanceEdit:528085] Kanapin, AA [InstanceEdit:615500] Kanapin, AA [InstanceEdit:797782] Kanapin, AA [InstanceEdit:937668] Yung, CK [InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301009] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266118] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:5618474] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name	ubiquitin activating enzyme activity
referenceDatabase	[ReferenceDatabase:1] GO
(activity)	[Requirement:9923965] Requirement by 'Ubiquitin activating E1 enzymes [cytosol]' [CatalystActivity:8865054] ubiquitin activating enzyme activity of Ub-Cys632-UBA1 [cytosol] [CatalystActivity:8865063] ubiquitin activating enzyme activity of UBA1 [cytosol] [CatalystActivity:8865076] ubiquitin activating enzyme activity of UBA6:ubiquitin adenylate [cytosol] [CatalystActivity:8865083] ubiquitin activating enzyme activity of UBA1:ubiquitin adenylate [cytosol] [CatalystActivity:8865189] ubiquitin activating enzyme activity of UBA6 [cytosol] [CatalystActivity:8865193] ubiquitin activating enzyme activity of Ub-Cys625-UBA6 [cytosol]
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No pathways have been reviewed or authored by ubiquitin activating enzyme activity (15143)