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Details on Person UniProt:Q86X67 NUDT13

Class:IdReferenceGeneProduct:151377
_chainChangeLogchain:1-352 added on Fri February 6 2015;chain:1-352 for 151377 removed on Wed February 17 2021;transit peptide:1-20 for 151377 added on Wed February 17 2021;chain:21-352 for 151377 added on Wed February 17 2021
_displayNameUniProt:Q86X67 NUDT13
_timestamp2025-02-21 18:39:39
chaintransit peptide:1-20
chain:21-352
checksum1FBBDB1ECD50BCAE
commentFUNCTION NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs.CATALYTIC ACTIVITY NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)CATALYTIC ACTIVITY NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)CATALYTIC ACTIVITY NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)COFACTOR Divalent metal cations. Mg(2+) or Mn(2+).SUBCELLULAR LOCATION Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.SIMILARITY Belongs to the Nudix hydrolase family.
created[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
descriptionrecommendedName: fullName evidence="7"NAD(P)H pyrophosphatase NUDT13, mitochondrial ecNumber evidence="1"3.6.1.22 alternativeName: Nucleoside diphosphate-linked moiety X motif 13 shortName: Nudix motif 13 alternativeName: Protein KiSS-16
geneNameNUDT13
identifierQ86X67
isSequenceChangedFALSE
keywordAlternative splicing
Hydrolase
Magnesium
Manganese
Metal-binding
Mitochondrion
NAD
NADP
Proteomics identification
Reference proteome
Transit peptide
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameNUDT13
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9004851] ENSEMBL:ENSG00000166321 NUDT13 [Homo sapiens]
secondaryIdentifierNUD13_HUMAN
B4DV90
O95650
Q5SQM4
Q5SQM5
Q5SQM6
Q9Y3X2
sequenceLength352
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:151378] UniProt:Q86X67-2 NUDT13 [Homo sapiens]
[ReferenceIsoform:409925] UniProt:Q86X67-1 NUDT13 [Homo sapiens]
[ReferenceIsoform:8973386] UniProt:Q86X67-3 NUDT13 [Homo sapiens]
[ReferenceIsoform:8973387] UniProt:Q86X67-4 NUDT13 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:6809216] NUDT13 [mitochondrial matrix] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q86X67 NUDT13 (151377)
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