Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9R1M7 Grin3a
| Class:Id | ReferenceGeneProduct:151148 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-1135 added on Fri February 6 2015 |
| _displayName | UniProt:Q9R1M7 Grin3a |
| _timestamp | 2025-02-21 19:40:47 |
| chain | signal peptide:1-23 chain:24-1135 |
| checksum | 8EC1FEEAE50AB237 |
| comment | FUNCTION Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (PubMed:11160393, PubMed:11823786, PubMed:11929923, PubMed:18003876). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (PubMed:25009255). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (PubMed:11929923). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:11823786). GluN3A subunit also binds D-serine (PubMed:18636091). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:11160393, PubMed:11929923). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)ACTIVITY REGULATION Excitatory glycine receptors are inhibited by D-serine at a concentrion of 10uM.SUBUNIT Heterotetramer. Forms heterotetrameric channels composed of two GluN1/zeta subunits (GRIN1), and two identical GluN3 subunits (GRIN3A or GRIN3B) (in vitro) (By similarity). Can also form heterotetrameric channels that contain at least two GluN1 subunits and at least a combination of one GluN2 and one GluN3 subunits (in vitro) (PubMed:11160393, PubMed:11929923, PubMed:12391275). Does not form functional homomeric channels (PubMed:11160393). Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB (PubMed:11588171). Probably interacts with PPP2CB (PubMed:11588171). No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (PubMed:11588171). Interacts (via C-terminus) with GIT1, but not with GRIA1/GluA1, nor with synaptophysin/SYP; this interaction competes with GIT1 interaction with ARHGEF7/beta-PIX (PubMed:24297929).SUBCELLULAR LOCATION Requires the presence of GRIN1 to be targeted at the plasma membrane.ALTERNATIVE PRODUCTS Isoform 1 and isoform 2 are expressed in olfactory bulb, frontal occipital, entorhinal and pyriform cortices, hippocampus, striatum, thalamus, cerebellum and spinal cord.DEVELOPMENTAL STAGE Isoform 1 and isoform 2 are expressed in spinal cord, medulla, pons, tegmentum, thalamus and hypothalamus at 15 dpc onwards (PubMed:7472412, PubMed:7472413, PubMed:9891978). In the brain cortex and in the hippocampus, strongly expressed during periods of synapse/spine reorganization at postnatal day 8 (P8) to P15. Expression declines after P25 (at protein level) (PubMed:24297929).PTM N-glycosylated.SIMILARITY Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="21"Glutamate receptor ionotropic, NMDA 3A shortName evidence="18"GluN3A alternativeName: fullName evidence="19"Glutamate receptor chi-1 alternativeName: N-methyl-D-aspartate receptor alternativeName: N-methyl-D-aspartate receptor subtype 3A shortName: NMDAR3A shortName evidence="2"NR3A alternativeName: fullName evidence="20"NMDAR-L alternativeName: NMDAR-L1 |
| geneName | Grin3a |
| identifier | Q9R1M7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cell membrane Coiled coil Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Magnesium Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Grin3a |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NMD3A_RAT O09098 O09155 Q62800 Q63268 Q9Z2H0 |
| sequenceLength | 1135 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:151149] UniProt:Q9R1M7-2 Grin3a [Rattus norvegicus] [ReferenceIsoform:415240] UniProt:Q9R1M7-1 Grin3a [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9610230] Grin3a [endoplasmic reticulum membrane] [Rattus norvegicus] [EntityWithAccessionedSequence:9610793] Grin3a [plasma membrane] [Rattus norvegicus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9R1M7 Grin3a (151148)
