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Details on Person UniProt:Q15788-3 NCOA1
| Class:Id | ReferenceIsoform:150892 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-1441 added on Sat February 7 2015;initiator methionine:1 for 150892 removed on Fri Nov 03 2023;initiator methionine: for 150892 added on Fri Nov 03 2023;initiator methionine: for 150892 removed on Fri Aug 15 2025;initiator methionine:1 for 150892 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q15788-3 NCOA1 |
| _timestamp | 2025-08-15 21:47:02 |
| chain | initiator methionine:1 chain:2-1441 |
| checksum | 25EF6F389489121E |
| comment | FUNCTION Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)SUBUNIT Interacts with PPARA; the interaction is direct (PubMed:11698662). Interacts with PPARG; the interaction is direct (PubMed:11698662, PubMed:9744270). Interacts with ESRRG; the interaction is direct (PubMed:11864604). Interacts with STAT5A (via FDL motif) (PubMed:12954634). Interacts with STAT5B (via FDL motif) (PubMed:12954634). Interacts with STAT6 (via LXXLL motif) (PubMed:12138096). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif) (By similarity). Interacts with ASXL1 (PubMed:16606617). Interacts with the methyltransferase CARM1 (By similarity). Interacts with COPS5 (PubMed:10722692). Interacts with the histone acetyltransferase CREBBP (By similarity). Interacts with DDX5 (PubMed:11250900). Interacts with the histone acetyltransferase EP300 (By similarity). Interacts with ESR1 (PubMed:7481822). Interacts with GCCR (PubMed:7481822). Interacts with the basal transcription factor GTF2B (PubMed:8754792). Interacts with NCOA6 (PubMed:10567404). Interacts with NCOA2 (PubMed:10594042). Interacts with NR3C1 (PubMed:12917342). Interacts with NR4A1/Nur77 (PubMed:18690216). Interacts with NR4A3 (By similarity). Interacts with PCAF (PubMed:9296499). Interacts with PGR (PubMed:7481822). Interacts with PRMT2 (PubMed:12039952). Interacts with PRMT6 (PubMed:20047962). Interacts with PSMB9 (PubMed:16957778). Interacts with RXRA, the interaction is ligand-dependent (PubMed:19786558, PubMed:7481822). Interacts with STAT3 following IL-6 stimulation (PubMed:11773079). Interacts with TRA (PubMed:7481822). Interacts with TRIP4 (PubMed:25219498). Interacts with TTLL5/STAMP (PubMed:17116691). Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity (PubMed:15367689). Interacts with VDR (PubMed:28698609).INTERACTION Widely expressed.DOMAIN The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.DOMAIN Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.PTM Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.PTM Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.DISEASE A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.MISCELLANEOUS Major form. Contains a domain at its C-terminus (1241-1399) that is able to mediate transactivation.SIMILARITY Belongs to the SRC/p160 nuclear receptor coactivator family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Nuclear receptor coactivator 1 shortName: NCoA-1 ecNumber: 2.3.1.48 alternativeName: Class E basic helix-loop-helix protein 74 shortName: bHLHe74 alternativeName: Protein Hin-2 alternativeName: RIP160 alternativeName: Renal carcinoma antigen NY-REN-52 alternativeName: Steroid receptor coactivator 1 shortName: SRC-1 |
| geneName | NCOA1 BHLHE74 SRC1 |
| identifier | Q15788 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Acyltransferase Alternative splicing Chromosomal rearrangement Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Repeat Transcription Transcription regulation Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NCOA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997846] ENSEMBL:ENSG00000084676 NCOA1 [Homo sapiens] |
| secondaryIdentifier | NCOA1_HUMAN O00150 O43792 O43793 Q13071 Q13420 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3 |
| sequenceLength | 1441 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q15788-3 |
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No pathways have been reviewed or authored by UniProt:Q15788-3 NCOA1 (150892)
