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Details on Person UniProt:Q92621 NUP205
| Class:Id | ReferenceGeneProduct:150795 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-2012 added on Sat February 7 2015;initiator methionine:1 for 150795 removed on Fri Nov 03 2023;initiator methionine: for 150795 added on Fri Nov 03 2023;initiator methionine: for 150795 removed on Fri Aug 15 2025;initiator methionine:1 for 150795 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q92621 NUP205 |
| _timestamp | 2025-08-15 21:24:56 |
| chain | initiator methionine:1 chain:2-2012 |
| checksum | F3B268881000FBAA |
| comment | FUNCTION Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065).SUBUNIT Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:9348540). Forms a complex with NUP35, NUP93, NUP155 and lamin B (PubMed:15703211, PubMed:26878725). Does not interact with TPR (PubMed:12802065). Interacts with TMEM209 and MYC (PubMed:18691976).INTERACTION Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure.TISSUE SPECIFICITY Expressed in the testis.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the NUP186/NUP192/NUP205 family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Nuclear pore complex protein Nup205 alternativeName: 205 kDa nucleoporin alternativeName: Nucleoporin Nup205 |
| geneName | NUP205 C7orf14 KIAA0225 |
| identifier | Q92621 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Disease variant Membrane mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NUP205 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002509] ENSEMBL:ENSG00000155561 NUP205 [Homo sapiens] |
| secondaryIdentifier | NU205_HUMAN A6H8X3 Q86YC1 |
| sequenceLength | 2012 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:157754] NUP205 [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:9634168] NUP205 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92621 NUP205 (150795)
