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Details on Person UniProt:Q8WXR4-5 MYO3B
| Class:Id | ReferenceIsoform:150716 |
|---|---|
| _chainChangeLog | chain:1-1341 added on Sat February 7 2015 |
| _displayName | UniProt:Q8WXR4-5 MYO3B |
| _timestamp | 2025-02-21 19:50:37 |
| chain | chain:1-1341 |
| checksum | 76F84C571DAA269D |
| comment | FUNCTION Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts (via C-terminus) with ESPN. Interacts (via C-terminus) with ESPNL.INTERACTION Expressed in retina, kidney and testis.SIMILARITY In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SIMILARITY In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Myosin-IIIb ecNumber: 2.7.11.1 |
| geneName | MYO3B |
| identifier | Q8WXR4 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Actin-binding Alternative splicing ATP-binding Cell projection Cytoplasm Cytoskeleton Hearing Kinase Motor protein Myosin Nucleotide-binding Proteomics identification Reference proteome Repeat Sensory transduction Serine/threonine-protein kinase Transferase Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MYO3B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994974] ENSEMBL:ENSG00000071909 MYO3B [Homo sapiens] |
| secondaryIdentifier | MYO3B_HUMAN B8ZZR2 Q53QE1 Q53T08 Q8IX64 Q8IX65 Q8IX66 Q8IX67 Q8IX68 Q96N94 |
| sequenceLength | 1341 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8WXR4-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8WXR4-5 MYO3B (150716)
