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Details on Person UniProt:Q8K3H5 Myo3a
| Class:Id | ReferenceGeneProduct:150711 |
|---|---|
| _chainChangeLog | chain:1-1613 added on Fri February 6 2015 |
| _displayName | UniProt:Q8K3H5 Myo3a |
| _timestamp | 2025-02-21 19:50:36 |
| chain | chain:1-1613 |
| checksum | 19DFD980BF7B8847 |
| comment | FUNCTION Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:26754646). Probably plays also a role in vision (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:19287378).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Interacts with MORN4 (PubMed:26754646). Interacts (via C-terminus) with ESPN and ESPNL (PubMed:26926603).SUBCELLULAR LOCATION Increased localization at the filodium tip seen in the presence of MORN4.TISSUE SPECIFICITY Expressed in the cochlear hair cells (at protein level) (PubMed:26754646). Expressed in utricle hair bundles (at protein level) (PubMed:26926603).DISRUPTION PHENOTYPE MYO3A single knockout mice do not exhibit early hearing impairment whereas mice with a double knockout of MYO3A and MYO3B are profoundly deaf at 1 month of age. Cochlear hair bundles have abnormally long stereocilia and show dynamic shape defects during development.SIMILARITY In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SIMILARITY In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Myosin-IIIa ecNumber: 2.7.11.1 |
| geneName | Myo3a |
| identifier | Q8K3H5 |
| isSequenceChanged | FALSE |
| keyword | Actin-binding ATP-binding Cell projection Cytoplasm Cytoskeleton Hearing Kinase Motor protein Myosin Nucleotide-binding Reference proteome Repeat Sensory transduction Serine/threonine-protein kinase Transferase Vision |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Myo3a |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MYO3A_MOUSE |
| sequenceLength | 1613 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9663309] Myo3a [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8K3H5 Myo3a (150711)
