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Details on Person DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex

Class:Id	Reaction:1504213
_displayName	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
_doRelease	TRUE
_timestamp	2025-08-29 19:55:18
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1504208] Rothfels, K, 2011-08-23
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input	[CandidateSet:1504201] DVL [cytosol] [Homo sapiens] [Complex:1504195] CUL3:KLHL12:RBX1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1504211] The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
modified	[InstanceEdit:3774844] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518436] Rothfels, K, 2013-09-03 [InstanceEdit:4641270] Rothfels, K, 2013-09-27 [InstanceEdit:4655148] Rothfels, K, 2013-10-02 [InstanceEdit:5097262] Rothfels, K, 2013-11-11 [InstanceEdit:5146721] Rothfels, K, 2013-11-18 [InstanceEdit:5251589] Rothfels, K, 2014-02-04 [InstanceEdit:5323567] Rothfels, K, 2014-02-15 [InstanceEdit:5576910] Rothfels, Karen, 2014-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9965547] Orlic-Milacic, Marija, 2025-08-29
name	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
negativePrecedingEvent	[NegativePrecedingEvent:9965514] Futile Cycle: Ubiquitinated DVL is degraded by the proteasome
output	[Complex:1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644342] R-HSA-1504213.3
summation	[Summation:1504199] In response to WNT signaling, DVL is recruited to the CUL3:K...
(hasEvent)	[Pathway:4641258] Degradation of DVL [Homo sapiens]
(precedingEvent)	[Reaction:1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 [Homo sapiens]
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No pathways have been reviewed or authored by DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (1504213)