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Details on Person DVL is ubiquitinated by CUL3:KLHL12:RBX1

Class:IdReaction:1504190
_displayNameDVL is ubiquitinated by CUL3:KLHL12:RBX1
_doReleaseTRUE
_timestamp2025-08-29 19:55:20
authored[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity[CatalystActivity:1504214] ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:1504208] Rothfels, K, 2011-08-23
edited[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input[Complex:1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1504211] The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
modified[InstanceEdit:3774840] Rothfels, K, 2013-06-25
[InstanceEdit:4416357] Rothfels, K, 2013-08-25
[InstanceEdit:4518433] Rothfels, K, 2013-09-03
[InstanceEdit:4641271] Rothfels, K, 2013-09-27
[InstanceEdit:4652683] Rothfels, K, 2013-10-02
[InstanceEdit:4652717] Rothfels, K, 2013-10-02
[InstanceEdit:4655149] Rothfels, K, 2013-10-02
[InstanceEdit:5097264] Rothfels, K, 2013-11-11
[InstanceEdit:5146720] Rothfels, K, 2013-11-18
[InstanceEdit:5251590] Rothfels, K, 2014-02-04
[InstanceEdit:5323569] Rothfels, K, 2014-02-15
[InstanceEdit:5576911] Rothfels, Karen, 2014-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9965547] Orlic-Milacic, Marija, 2025-08-29
nameDVL is ubiquitinated by CUL3:KLHL12:RBX1
negativePrecedingEvent[NegativePrecedingEvent:9965530] Abundant Molecules: USP34 deubiquitinates AXIN1,AXIN2
[NegativePrecedingEvent:9965531] Abundant Molecules: USP8 deubiquitinates FZD to potentiate WNT signaling
[NegativePrecedingEvent:9965533] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965512] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965504] Abundant Molecules: Ubiquitinated DVL is degraded by the proteasome
[NegativePrecedingEvent:9965536] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
output[Complex:4652690] ub-DVL:CUL3:KLHL12:RBX1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2014-03-12
reviewed[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644722] R-HSA-1504190.3
summation[Summation:1504191] CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it...
(hasEvent)[Pathway:4641258] Degradation of DVL [Homo sapiens]
(precedingEvent)[BlackBoxEvent:1504193] Ubiquitinated DVL is degraded by the proteasome [Homo sapiens]
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