Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person AMER1 [cytosol]

Class:IdEntityWithAccessionedSequence:1504189
_displayNameAMER1 [cytosol]
_timestamp2013-05-28 19:19:39
compartment[Compartment:70101] cytosol
created[InstanceEdit:1504208] Rothfels, K, 2011-08-23
endCoordinate1135
modified[InstanceEdit:3632907] Wu, G, 2013-05-28
nameAMER1
FAM123B
WTX
referenceEntity[ReferenceGeneProduct:228772] UniProt:Q5JTC6 AMER1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1591749] R-HSA-1504189.1
startCoordinate1
(hasComponent)[Complex:195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:195322] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:196222] p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:5339714] p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
[Complex:9666609] phosphorylated ubiquitination mutants of CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Homo sapiens]
(input)[Reaction:195251] Assembly of the destruction complex [Homo sapiens]
[FailedReaction:4791278] APC truncation mutants have impaired AXIN binding [Homo sapiens]
[FailedReaction:4839734] AXIN mutants destabilize the destruction complex [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:4839739] loss_of_function of truncated AMER1 mutants [cytosol]
(output)[Reaction:201685] Beta-catenin is released from the destruction complex [Homo sapiens]
[BlackBoxEvent:5251557] Expression of AMER1 gene [Homo sapiens]
(regulator)[NegativeRegulation:9795924] Negative regulation by 'AMER1 [cytosol]'
(updatedInstance)[_UpdateTracker:9882855] Update Tracker - [EntityWithAccessionedSequence:1504189] AMER1 [cytosol] - v45:[addName]
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No pathways have been reviewed or authored by AMER1 [cytosol] (1504189)