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Details on Person UniProt:Q8R431 Mgll

Class:Id	ReferenceGeneProduct:150286
_chainChangeLog	chain:1-303 added on Fri February 6 2015
_displayName	UniProt:Q8R431 Mgll
_timestamp	2025-02-21 19:09:19
chain	chain:1-303
checksum	49CD407D97A1A971
comment	FUNCTION Converts monoacylglycerides to free fatty acids and glycerol (PubMed:12136125). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:12136125, PubMed:17649977). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).CATALYTIC ACTIVITY Hydrolyzes glycerol monoesters of long-chain fatty acids.CATALYTIC ACTIVITY a 1-acylglycerol + H2O = glycerol + a fatty acid + H(+)CATALYTIC ACTIVITY a 2-acylglycerol + H2O = glycerol + a fatty acid + H(+)CATALYTIC ACTIVITY 1-octanoylglycerol + H2O = octanoate + glycerol + H(+)CATALYTIC ACTIVITY 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-decanoylglycerol + H2O = decanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-tetradecanoylglycerol + H2O = tetradecanoate + glycerol + H(+)CATALYTIC ACTIVITY 2-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 1-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-octadecanoylglycerol + H2O = octadecanoate + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin E2 1-glyceryl ester + H2O = prostaglandin E2 + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin D2-1-glycerol ester + H2O = prostaglandin D2 + glycerol + H(+)CATALYTIC ACTIVITY 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)CATALYTIC ACTIVITY prostaglandin F2alpha 1-glyceryl ester + H2O = prostaglandin F2alpha + glycerol + H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 21 min(-1) with 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol).PATHWAY Glycerolipid metabolism; triacylglycerol degradation.SUBUNIT Homodimer.SUBCELLULAR LOCATION Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain.MISCELLANEOUS Requires non-ionic detergent for solubilization.MISCELLANEOUS Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.SIMILARITY Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
description	recommendedName: fullName evidence="7"Monoglyceride lipase shortName: MGL ecNumber evidence="5"3.1.1.23 alternativeName: Monoacylglycerol lipase shortName: MAGL
geneName	Mgll Mgl2
identifier	Q8R431
isSequenceChanged	FALSE
keyword	Cytoplasm Direct protein sequencing Fatty acid biosynthesis Fatty acid metabolism Hydrolase Lipid biosynthesis Lipid degradation Lipid metabolism Membrane Nitration Phosphoprotein Reference proteome Serine esterase
modified	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	Mgll
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	MGLL_RAT Q32PZ2
sequenceLength	303
species	[Species:48895] Rattus norvegicus
(referenceEntity)	[EntityWithAccessionedSequence:163545] monoglyceride lipase [lipid droplet] [Rattus norvegicus] [EntityWithAccessionedSequence:9917966] rMgll [lipid droplet] [Rattus norvegicus]
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No pathways have been reviewed or authored by UniProt:Q8R431 Mgll (150286)