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Details on Person UniProt:P08235-2 NR3C2
| Class:Id | ReferenceIsoform:150160 |
|---|---|
| _chainChangeLog | chain:1-984 added on Fri February 6 2015 |
| _displayName | UniProt:P08235-2 NR3C2 |
| _timestamp | 2026-02-20 22:45:41 |
| chain | chain:1-984 |
| checksum | 833D900F2CB27390 |
| comment | FUNCTION Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.SUBUNIT Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.INTERACTION Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.PTM Phosphorylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Lacks steroid-binding activity and acts as ligand-independent transactivator.SIMILARITY Belongs to the nuclear hormone receptor family. NR3 subfamily.ONLINE INFORMATION Mineralocorticoid receptor entry |
| description | recommendedName: Mineralocorticoid receptor shortName: MR alternativeName: Nuclear receptor subfamily 3 group C member 2 |
| geneName | NR3C2 MCR MLR |
| identifier | P08235 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disease variant DNA-binding Endoplasmic reticulum Lipid-binding Membrane Metal-binding Nucleus Phosphoprotein Proteomics identification Receptor Reference proteome Steroid-binding Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NR3C2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004235] ENSEMBL:ENSG00000151623 NR3C2 [Homo sapiens] |
| secondaryIdentifier | MCR_HUMAN B0ZBF5 B0ZBF7 Q2NKL1 Q96KQ8 Q96KQ9 |
| sequenceLength | 984 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P08235-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:3196183] NR3C2-2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08235-2 NR3C2 (150160)
