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Details on Person UniProt:Q9Z2D8 Mbd3
| Class:Id | ReferenceGeneProduct:150083 |
|---|---|
| _chainChangeLog | chain:1-285 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Z2D8 Mbd3 |
| _timestamp | 2026-02-20 21:50:59 |
| chain | chain:1-285 |
| checksum | E4E57BD48463643F |
| comment | FUNCTION Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself (PubMed:9774669). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity).SUBUNIT Heterodimer (via N-terminus) with MBD2 (By similarity). Component of the MeCP1 histone deacetylase complex (By similarity). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity). Interacts with MBD3L2 (via N-terminus); the interaction is direct (By similarity). Interacts with BCL6 (By similarity). Interacts with CDK2AP1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with MTA2 (By similarity). Interacts with DNMT1 (By similarity). Interacts with GATAD2A (By similarity). Interacts with GATAD2B (By similarity). Does not interact with PWWP2A (PubMed:30228260, PubMed:30327463). Does not interact with PWWP2B (PubMed:30228260).SUBCELLULAR LOCATION Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci (PubMed:9774669).ALTERNATIVE PRODUCTS Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Methyl-CpG-binding domain protein 3 alternativeName: Methyl-CpG-binding protein MBD3 |
| geneName | Mbd3 |
| identifier | Q9Z2D8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromosome Coiled coil DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Mbd3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MBD3_MOUSE Q792D3 Q8CFJ1 |
| sequenceLength | 285 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:150084] UniProt:Q9Z2D8-2 Mbd3 [Mus musculus] [ReferenceIsoform:416240] UniProt:Q9Z2D8-1 Mbd3 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:5096450] Mbd3 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9Z2D8 Mbd3 (150083)
