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Details on Person UniProt:Q9UBB5 MBD2
| Class:Id | ReferenceGeneProduct:150076 |
|---|---|
| _chainChangeLog | chain:1-411 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UBB5 MBD2 |
| _timestamp | 2024-11-03 19:52:32 |
| chain | chain:1-411 |
| checksum | FC4E5E0CF9BA0FFA |
| comment | FUNCTION Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568).SUBUNIT Heterodimer with MBD3 (via N-terminus) (PubMed:10947852, PubMed:15701600). Component of the MeCP1 complex that contains HDAC1 and HDAC2 (PubMed:10471499, PubMed:11102443). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:27732854, PubMed:28977666, PubMed:33283408). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). Interacts with CDK2AP1 (PubMed:20523938). Interacts with DHX9 (PubMed:12665568). Interacts with DNMT1 (PubMed:10947852). Interacts with GATAD2A/p66-alpha (PubMed:12183469, PubMed:16415179, PubMed:21490301, PubMed:27732854, PubMed:33283408). Interacts with GATAD2B/p66-beta (PubMed:12183469, PubMed:16415179, PubMed:27732854). Interacts with GPN1 (PubMed:12588985). Interacts with MIZF (PubMed:11553631). Interacts with PRMT5 (PubMed:16428440). Interacts with SIN3A (PubMed:10950960). Interacts with SPHK2 (PubMed:19729656).INTERACTION Nuclear, in discrete foci (PubMed:12183469). Detected at replication foci in late S phase. Localizes to methylated chromatin (PubMed:16428440). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854).ALTERNATIVE PRODUCTS Highly expressed in brain, heart, kidney, stomach, testis and placenta.MISCELLANEOUS Incomplete sequence.CAUTION Functional studies (PubMed:10050851, PubMed:10950960, PubMed:12665568) have used a C-terminal fragment of isoform 1 which has been described originally as isoform MBD2b but cannot however be proven by supporting cDNA sequences. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="24"Methyl-CpG-binding domain protein 2 alternativeName: Demethylase shortName: DMTase alternativeName: Methyl-CpG-binding protein MBD2 |
| geneName | MBD2 |
| identifier | Q9UBB5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromosome DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MBD2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996700] ENSEMBL:ENSG00000134046 MBD2 [Homo sapiens] |
| secondaryIdentifier | MBD2_HUMAN O95242 Q9UIS8 |
| sequenceLength | 411 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150078] UniProt:Q9UBB5-3 MBD2 [Homo sapiens] [ReferenceIsoform:415286] UniProt:Q9UBB5-1 MBD2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:427367] MBD2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UBB5 MBD2 (150076)
