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Details on Person PIK3CA H1047R [cytosol]
Class:Id EntityWithAccessionedSequence:1500716 _displayName PIK3CA H1047R [cytosol] _timestamp 2013-06-06 16:42:23 compartment [Compartment:70101] cytosol created [InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19 crossReference [DatabaseIdentifier:2362393] COSMIC:COSV55873195 [DatabaseIdentifier:2395921] COSMIC:COSM29325 disease [Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:1247632] glioblastoma [Disease:1500575] ovarian cancer [Disease:2317358] endometrial cancer [Disease:2328198] pancreatic cancer [Disease:1500699] lung cancer [Disease:2327997] pharynx cancer [Disease:1493885] bladder carcinoma [Disease:1614289] melanoma [Disease:2317371] ovarian endometrioid neoplasm [Disease:2328196] pituitary adenoma [Disease:1655470] thyroid cancer [Disease:1996312] brain glioma [Disease:2318519] medulloblastoma [Disease:2318576] oral cavity cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:2328081] non-Hodgkin lymphoma [Disease:1655499] prostate cancer [Disease:2327993] hepatocellular carcinoma [Disease:1614672] cervical cancer [Disease:2362392] brain meningioma [Disease:2362396] peripheral primitive neuroectodermal tumor [Disease:2362395] dysembryoplastic neuroepithelial tumor [Disease:2327996] gallbladder carcinoma [Disease:2396014] seborrheic keratosis endCoordinate 1068 hasModifiedResidue [ReplacedResidue:1500690] L-histidine 1047 replaced with L-arginine literatureReference [LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells [LiteratureReference:2399642] Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases modified [InstanceEdit:2362397] Orlic-Milacic, M, 2012-06-27 [InstanceEdit:2395926] Orlic-Milacic, M, 2012-07-05 [InstanceEdit:2396017] Orlic-Milacic, M, 2012-07-09 [InstanceEdit:2399648] Orlic-Milacic, M, 2012-07-11 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 name PIK3CA H1047R referenceEntity [ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA [Homo sapiens] species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2465530] R-HSA-1500716.1 startCoordinate 1 summation [Summation:2399644] Substitution of histidine residue with arginine at position ... (hasMember) [CandidateSet:2399596] PIK3CA kinase domain mutants [cytosol] [Homo sapiens] (updatedInstance) [_UpdateTracker:9887911] Update Tracker - [EntityWithAccessionedSequence:1500716] PIK3CA H1047R [cytosol] - v46:[modifyName]
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Pathways
No pathways have been reviewed or authored by PIK3CA H1047R [cytosol] (1500716)
