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Query author contributions in Reactome

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Details on Person PIK3CA E545G [cytosol]

Class:IdEntityWithAccessionedSequence:1500709
_displayNamePIK3CA E545G [cytosol]
_timestamp2013-06-06 16:42:22
compartment[Compartment:70101] cytosol
created[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference[DatabaseIdentifier:2328084] COSMIC:COSV55873220
disease[Disease:1248674] large intestine cancer
[Disease:1500689] cancer
[Disease:1493885] bladder carcinoma
[Disease:2317358] endometrial cancer
[Disease:1500576] breast cancer
[Disease:2327990] pituitary cancer
[Disease:2206359] retinoblastoma
[Disease:1500687] stomach cancer
[Disease:2318576] oral cavity cancer
[Disease:1247687] chronic myeloid leukemia
[Disease:2328081] non-Hodgkin lymphoma
[Disease:2328083] larynx cancer
[Disease:1248679] head and neck squamous cell carcinoma
[Disease:2396015] epidermal nevus
endCoordinate1068
hasModifiedResidue[ReplacedResidue:1500703] L-glutamic acid 545 replaced with glycine
literatureReference[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers
[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
[LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
modified[InstanceEdit:2328085] Orlic-Milacic, M, 2012-06-22
[InstanceEdit:2396017] Orlic-Milacic, M, 2012-07-09
[InstanceEdit:2399603] Orlic-Milacic, M, 2012-07-11
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
namePIK3CA E545G
PIK3CA Glu545Gly
referenceEntity[ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2465463] R-HSA-1500709.1
startCoordinate1
summation[Summation:2399585] Based on structural and functional studies of the PIK3CA E54...
(hasCandidate)[CandidateSet:2399587] PIK3CA helical domain mutants [cytosol] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9887587] Update Tracker - [EntityWithAccessionedSequence:1500709] PIK3CA E545G [cytosol] - v46:[modifyName]
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No pathways have been reviewed or authored by PIK3CA E545G [cytosol] (1500709)