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Details on Person PIK3CA E545K [cytosol]

Class:IdEntityWithAccessionedSequence:1500706
_displayNamePIK3CA E545K [cytosol]
_timestamp2013-06-06 16:42:22
compartment[Compartment:70101] cytosol
created[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference[DatabaseIdentifier:2328087] COSMIC:COSV55873239
[DatabaseIdentifier:2328088] COSMIC:COSM29328
disease[Disease:1248674] large intestine cancer
[Disease:1500699] lung cancer
[Disease:1500689] cancer
[Disease:1500576] breast cancer
[Disease:1500687] stomach cancer
[Disease:2327996] gallbladder carcinoma
[Disease:1614289] melanoma
[Disease:1500575] ovarian cancer
[Disease:2317358] endometrial cancer
[Disease:1493885] bladder carcinoma
[Disease:2327997] pharynx cancer
[Disease:2327994] penis carcinoma
[Disease:2327998] esophageal carcinoma
[Disease:2327989] bile duct carcinoma
[Disease:1614672] cervical cancer
[Disease:1655470] thyroid cancer
[Disease:1247632] glioblastoma
[Disease:2318519] medulloblastoma
[Disease:1996312] brain glioma
[Disease:2328000] gum cancer
[Disease:1248679] head and neck squamous cell carcinoma
[Disease:2328001] skin squamous cell carcinoma
[Disease:1655484] kidney cancer
[Disease:2328197] renal pelvis carcinoma
[Disease:2328200] tongue cancer
[Disease:2328202] eccrine sweat gland cancer
[Disease:2328198] pancreatic cancer
[Disease:2328196] pituitary adenoma
[Disease:2328199] basal cell carcinoma
[Disease:2328201] myeloma
[Disease:2396014] seborrheic keratosis
endCoordinate1068
hasModifiedResidue[ReplacedResidue:1500692] L-glutamic acid 545 replaced with L-lysine
literatureReference[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers
[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
modified[InstanceEdit:2328089] Orlic-Milacic, M, 2012-06-22
[InstanceEdit:2328204] Orlic-Milacic, M, 2012-06-25
[InstanceEdit:2362368] Orlic-Milacic, M, 2012-06-27
[InstanceEdit:2396017] Orlic-Milacic, M, 2012-07-09
[InstanceEdit:2399603] Orlic-Milacic, M, 2012-07-11
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
namePIK3CA E545K
PIK3CA Glu545Lys
referenceEntity[ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2465292] R-HSA-1500706.1
startCoordinate1
summation[Summation:2399586] Substitution of glutamic acid residue at position 545 of PIK...
(hasMember)[CandidateSet:2399587] PIK3CA helical domain mutants [cytosol] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9888245] Update Tracker - [EntityWithAccessionedSequence:1500706] PIK3CA E545K [cytosol] - v46:[modifyName]
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No pathways have been reviewed or authored by PIK3CA E545K [cytosol] (1500706)
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