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Details on Person cancer

Class:Id	Disease:1500689
_displayName	cancer
_timestamp	2011-08-19 16:25:38
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
definition	A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
identifier	162
name	cancer
referenceDatabase	[ReferenceDatabase:1247631] DOID
synonym	malignant tumor malignant neoplasm primary cancer
(disease)	[Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Reaction:1218824] HSP90 is inactivated by binding to benzaquinoid ansamycins [Homo sapiens] [Reaction:1218833] Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 [Homo sapiens] [Reaction:1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants [Homo sapiens] [Reaction:1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors [Homo sapiens] [Reaction:1220612] Binding of EGF to ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1220613] EGF-induced dimerization of ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1220614] Spontaneous dimerization of ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens] List all 6205 refering instances
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No pathways have been reviewed or authored by cancer (1500689)