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Details on Person UniProt:Q13477-1 MADCAM1
| Class:Id | ReferenceIsoform:150026 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-382 added on Fri February 6 2015 |
| _displayName | UniProt:Q13477-1 MADCAM1 |
| _timestamp | 2024-11-03 20:10:42 |
| chain | signal peptide:1-18 chain:19-382 |
| checksum | 9DCA60C30BA61E62 |
| comment | FUNCTION Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.SUBUNIT Homodimer.SUBCELLULAR LOCATION Additional isoforms seem to exist.TISSUE SPECIFICITY Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.PTM The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.POLYMORPHISM The number of repeats in the mucin domain varies between 5 and 8 repeats. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Mucosal addressin cell adhesion molecule 1 shortName: MAdCAM-1 shortName: hMAdCAM-1 |
| geneName | MADCAM1 |
| identifier | Q13477 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell adhesion Disulfide bond Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MADCAM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001888] ENSEMBL:ENSG00000099866 MADCAM1 [Homo sapiens] |
| secondaryIdentifier | MADCA_HUMAN A5PKV4 B2RPL9 O60222 O75867 Q5UGI7 |
| sequenceLength | 382 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13477-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:198095] MADCAM1-1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13477-1 MADCAM1 (150026)
