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Details on Person Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)

Class:Id	Reaction:1497878
_displayName	Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
_doRelease	TRUE
_timestamp	2024-08-01 19:19:05
authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
crossReference	[DatabaseIdentifier:9911123] RHEA:51189
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
input	[SimpleEntity:202124] NO [cytosol] [SimpleEntity:1222424] O2.- [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1497801] Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo [LiteratureReference:1497833] Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
modified	[InstanceEdit:1497959] Jassal, B, 2011-08-17 [InstanceEdit:1502547] Jassal, B, 2011-08-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
name	Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) nitric oxide + superoxide => peroxynitrite
output	[SimpleEntity:1222481] Peroxynitrite [cytosol]
precedingEvent	[Reaction:1497810] Uncoupled eNOS favours the formation of superoxide [Homo sapiens] [Reaction:1497796] BH2 binding can lead to eNOS uncoupling [Homo sapiens] [Reaction:202127] eNOS synthesizes NO [Homo sapiens] [Reaction:1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591308] R-HSA-1497878.3
summation	[Summation:1497876] Superoxide (O2.-) formed from an uncoupled eNOS action, toge...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens]
(precedingEvent)	[Reaction:1497866] Peroxynitrite can oxidise BH4 to the BH3 radical [Homo sapiens]
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No pathways have been reviewed or authored by Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (1497878)