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Details on Person UniProt:Q86W92 PPFIBP1
| Class:Id | ReferenceGeneProduct:149787 |
|---|---|
| _chainChangeLog | chain:1-1011 added on Fri February 6 2015 |
| _displayName | UniProt:Q86W92 PPFIBP1 |
| _timestamp | 2024-11-03 20:01:39 |
| chain | chain:1-1011 |
| checksum | 20E30DD99ACD5A92 |
| comment | FUNCTION May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.SUBUNIT Forms homodimers and heterodimers. Interacts with S100A4 in a Ca(2+)-dependent mode (PubMed:11836260). Part of a cortical microtubule stabilization complex (CMSC) composed of KANK1, PPFIA1, PPFIBP1, ERC1/ELKS, PHLDB2/LL5beta, CLASPs, KIF21A and possibly additional interactors; within CMSCs KANK1 and PHLDB2/LL5beta seem to be the core components for recruiting microtubule-binding proteins KIF21A and CLASPs, whereas PPFIA1, PPFIBP1 and ERC1/ELKS serve as scaffolds for protein clustering. Interacts with KANK1 (via CC1 domain, residues 244-339) (PubMed:24120883, PubMed:27410476).INTERACTION Widely expressed. Absent in liver.DOMAIN The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Due to intron retention.SIMILARITY Belongs to the liprin family. Liprin-beta subfamily.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Liprin-beta-1 alternativeName: Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1 shortName: PTPRF-interacting protein-binding protein 1 alternativeName: hSGT2 |
| geneName | PPFIBP1 KIAA1230 |
| identifier | Q86W92 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Coiled coil Cytoplasm Disease variant Epilepsy Intellectual disability Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PPFIBP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987918] ENSEMBL:ENSG00000110841 PPFIBP1 [Homo sapiens] |
| secondaryIdentifier | LIPB1_HUMAN O75336 Q86X70 Q9NY03 Q9ULJ0 |
| sequenceLength | 1011 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149788] UniProt:Q86W92-2 PPFIBP1 [Homo sapiens] [ReferenceIsoform:149789] UniProt:Q86W92-3 PPFIBP1 [Homo sapiens] [ReferenceIsoform:149790] UniProt:Q86W92-4 PPFIBP1 [Homo sapiens] [ReferenceIsoform:149791] UniProt:Q86W92-5 PPFIBP1 [Homo sapiens] [ReferenceIsoform:409900] UniProt:Q86W92-1 PPFIBP1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6799300] PPFIBP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711955] PPFIBP1(1-349)insK-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711961] PPFIBP1(1-349)insK-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711963] PPFIBP1(1-232)-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711976] PPFIBP1(1-232)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] |
| (referenceSequence) | [FragmentReplacedModification:9711924] Replacement of residues 349 to 349 by KK |
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No pathways have been reviewed or authored by UniProt:Q86W92 PPFIBP1 (149787)
