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Details on Person BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle

Class:Id	Reaction:1497824
_displayName	BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle
_doRelease	TRUE
_timestamp	2011-09-09 08:57:07
authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
input	[SimpleEntity:29870] BH4 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1497844] Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase
modified	[InstanceEdit:1497959] Jassal, B, 2011-08-17 [InstanceEdit:1502546] Jassal, B, 2011-08-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle
output	[SimpleEntity:1497797] BH3. [cytosol] [SimpleEntity:879326] e- [cytosol]
precedingEvent	[Reaction:1475414] PTHP is reduced to BH4 by sepiapterin reductase (SPR) [Homo sapiens] [Reaction:1474184] DHNTP is dephosphorylated by PTPS to PTHP [Homo sapiens] [Reaction:1497853] Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II [Homo sapiens] [Reaction:1497883] Ferrous iron reduces the BH3 radical back to BH4 [Homo sapiens] [Reaction:1497855] Ascorbate can reduce the BH3 radical back to BH4 [Homo sapiens] [Reaction:1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle [Homo sapiens] [Reaction:1497883] Ferrous iron reduces the BH3 radical back to BH4 [Homo sapiens] [Reaction:1497824] BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591276] R-HSA-1497824.2
summation	[Summation:1497785] BH4 donates an electron to the eNOS catalytic cycle and is o...
(hasEvent)	[Pathway:1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [Homo sapiens]
(precedingEvent)	[Reaction:1497855] Ascorbate can reduce the BH3 radical back to BH4 [Homo sapiens] [BlackBoxEvent:1497863] The BH3 radical can decay to dihydrobiopterin (BH2) [Homo sapiens] [Reaction:1497883] Ferrous iron reduces the BH3 radical back to BH4 [Homo sapiens]
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