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Details on Person The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

Class:Id	Reaction:1497784
_displayName	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
_doRelease	TRUE
_timestamp	2024-08-02 15:43:31
authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:9911133] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9911132] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
input	[Complex:202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Homo sapiens] [SimpleEntity:29870] BH4 [cytosol]
internalReviewed	[InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
isChimeric	FALSE
literatureReference	[LiteratureReference:1497844] Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase [LiteratureReference:1497803] Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain
modified	[InstanceEdit:1497959] Jassal, B, 2011-08-17 [InstanceEdit:1502547] Jassal, B, 2011-08-23 [InstanceEdit:9026716] Rothfels, Karen, 2017-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917335] D'Eustachio, Peter, 2024-08-02
name	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
output	[Complex:1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:202111] AKT1 phosphorylates eNOS [Homo sapiens] [Reaction:202137] AKT1 binds eNOS complex via HSP90 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-09-20
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591391] R-HSA-1497784.4
structureModified	[InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation	[Summation:1497780] The cofactor tetrahydrobiopterin (BH4) ensures endothelial n...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens] [Pathway:1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent)	[Reaction:202127] eNOS synthesizes NO [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919473] Update Tracker - [Reaction:1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - v90:[removeCatalystActivity, removeLiteratureReference]
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