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Details on Person UniProt:O75334 PPFIA2
| Class:Id | ReferenceGeneProduct:149778 |
|---|---|
| _chainChangeLog | chain:1-1257 added on Fri February 6 2015 |
| _displayName | UniProt:O75334 PPFIA2 |
| _timestamp | 2024-11-03 20:01:39 |
| chain | chain:1-1257 |
| checksum | BD77601F444EEE10 |
| comment | FUNCTION Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165).SUBUNIT Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with KIF1A; the interaction decreases in presence of calcium (PubMed:30021165).SUBCELLULAR LOCATION Colocalizes with PTPRF at the cell surface.ALTERNATIVE PRODUCTS Expressed only in brain.DOMAIN The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.SIMILARITY Belongs to the liprin family. Liprin-alpha subfamily. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Liprin-alpha-2 alternativeName: Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2 shortName: PTPRF-interacting protein alpha-2 |
| geneName | PPFIA2 |
| identifier | O75334 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell projection Coiled coil Cytoplasm Phosphoprotein Proteomics identification Reference proteome Repeat Synapse |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PPFIA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002435] ENSEMBL:ENSG00000139220 PPFIA2 [Homo sapiens] |
| secondaryIdentifier | LIPA2_HUMAN B3KVT5 B3KXA0 B7Z2A6 B7Z3U9 B7Z663 B7ZKZ5 E7ERB8 E7ETG6 F8VP68 Q2M3G8 |
| sequenceLength | 1257 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977075] UniProt:O75334-1 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977076] UniProt:O75334-2 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977077] UniProt:O75334-3 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977078] UniProt:O75334-4 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977079] UniProt:O75334-5 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977080] UniProt:O75334-6 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977081] UniProt:O75334-7 PPFIA2 [Homo sapiens] [ReferenceIsoform:8977082] UniProt:O75334-8 PPFIA2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:383380] PPFIA2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6799316] PPFIA2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75334 PPFIA2 (149778)
