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Details on Person UniProt:P33121-2 ACSL1
| Class:Id | ReferenceIsoform:149580 |
|---|---|
| _chainChangeLog | chain:1-698 added on Fri February 6 2015 |
| _displayName | UniProt:P33121-2 ACSL1 |
| _timestamp | 2025-02-21 19:03:53 |
| chain | chain:1-698 |
| checksum | FD6669453589D362 |
| comment | FUNCTION Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).CATALYTIC ACTIVITY a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 3,7,11,15-tetramethylhexadecanoate + ATP + CoA = phytanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 2,6,10,14-tetramethylpentadecanoate + ATP + CoA = pristanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphateCOFACTOR Inhibited at high temperature and by arachidonate.SUBCELLULAR LOCATION Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.DEVELOPMENTAL STAGE Expressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes.MISCELLANEOUS May be due to a competing acceptor splice site.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. |
| description | recommendedName: fullName evidence="11"Long-chain-fatty-acid--CoA ligase 1 ecNumber evidence="7 8"6.2.1.3 alternativeName: Acyl-CoA synthetase 1 shortName: ACS1 alternativeName: Arachidonate--CoA ligase ecNumber evidence="2"6.2.1.15 alternativeName: Long-chain acyl-CoA synthetase 1 shortName: LACS 1 alternativeName: Long-chain acyl-CoA synthetase 2 shortName: LACS 2 alternativeName: Long-chain fatty acid-CoA ligase 2 alternativeName: Palmitoyl-CoA ligase 1 alternativeName: Palmitoyl-CoA ligase 2 alternativeName: Phytanate--CoA ligase ecNumber evidence="2"6.2.1.24 |
| geneName | ACSL1 FACL1 FACL2 LACS LACS1 LACS2 |
| identifier | P33121 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing ATP-binding Direct protein sequencing Endoplasmic reticulum Fatty acid metabolism Glycoprotein Ligase Lipid metabolism Magnesium Membrane Microsome Mitochondrion Mitochondrion outer membrane Nitration Nucleotide-binding Peroxisome Phosphoprotein Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACSL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5649894] ENSEMBL:ENSG00000151726 ACSL1 [Homo sapiens] |
| secondaryIdentifier | ACSL1_HUMAN B7Z452 D3DP57 P41215 Q8N8V7 Q8TA99 |
| sequenceLength | 698 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P33121-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P33121-2 ACSL1 (149580)
